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Cyclin E1 is a member of the highly conserved cyclin familia, whose members exhibit a dramatic periodicity of protein abundance throughout the cell cycle. CCNE1, an essential cyclin activating Cdk2, regulates G1-S phase transition in the mammalian cell divide cycle. Its timing expression is crucial for the initiation and control of DNA replication, histone biosynthesis and the centrosome cycle. 

Clinically, CCNE1 is associated with disease progression in many malignancies and a poor prognosis. Cyclin E1 contains two Cdc4 phosphodegron. One is an N-terminal Cdc4 phosphodegron, which includes the phosphorylated Thr62 residue. You can check out this link, if you want to buy Cyclin E1 antibody kit.

The G1/S cyclins E1 (and E2) are cyclins E1-E2.7 Transcription of cyclin E is controlled by E2F which is activated by cyclin D–CDK4/6-stimulated phosphorylation RB. The levels of cyclin E protein activity are highest in the late G1 and early S phase.

Cyclin ECDK2 phosphorylates RB at different sites than cyclin DK4/6. These kinases could differentially affect the interaction between RB, E2Fs and HDACs. Consequently, cyclin ECDK2 phosphorylates substrates that are more directly involved with the control of DNA replication and centrosome duplication.

This suggests that cyclin ECDK2 is at the interface of core cell cycle machinery and G1 regulation during S phase. Cyclin E1 forms a complex with CDK2 and serves as a regulatory component of CDK2. This activity is essential for cell cycle G1/S, which determines cell divide. 

Cyclin E/CDK2 is responsible for cell cycle progression and phosphorylates nucleophosmin. Cyclin E1 antibody overexpression is associated with tumorigenesis. It plays a role in many types of cancers including breast, colon and bladder cancers as well skin and lung cancers.

What Is Cyclin E1 Antibody?